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KMID : 0352119890050030384
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Journal of Kyung Hee University
1989 Volume.5 No. 3 p.384 ~ p.394
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EFFECT OF CORTISONE ON RENAL HANDLING OF Li^(+) AND Li+-INDUCED DIURESIS IN ADRENALECTOMIZED RABBITS
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Abstract
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In the previous experiment, impaired excretion of Li+ and insufficient Li´ associated withs glucocorticoids alone, the effect: of cortisone replacement on Li+ clearance and it´s response to diuresis were studied in adrenalectornized rabbits.
Bilateral adrenalectomy was performed on the rabbits subsequent to surgery, and animals were divided into two groups of eight rabbits each. One group received no steroid treatment while the other groups were maintained on hydrocortisone and cortisone for 5 days.
All animals received NaCl of 0.3 gm/kg/day for five days. On the morning of the fifth day after surgery, each animal had voided, and baseline blood sample was withdrawn. And then single intravenous
injectio n of Li´ (2 mEq/kg) in the form of LiCI was done.
Time urine collections of 10, 30 and 60 minutes after I. i´ pulse were obtained sequentially; arterial blood amples were drawn after every other urine collect on.
Plasma and urine concentration of Li+, Na´, K+ and os nolarity were measured and in accordance with c. -ine flow rate, urinary excretion rates and clearw ces of them were calculated.
The following results were obtained:
1) In cortisone treated rabbits, mean plasma concentration of Li´, Na+, K+, and osmolarity were somew iat higher than those of untreated rabbits but were r A significantly different because of the relative;y Large deviations.
2) Cc,rtisone did not show any detectable changes in urinr,ry concentrations of Li+, Na´, K´ or osmolarity.
3) U -ine flow rates were tenden to be higher before and after Li+ pulse and were significantly elevated at 60 minutes of Li´ in cortisone treated rabbits as compared to untreated rabbits.
4) Cortisone treated rabbits responden to exogenous Li´ by greater natriuresis, kaliuresis, osmola r excertion than did untreated rabbits.
5) Administration of hydrocortisone significantly led to a n elevating Li´ clearance during entire course of exp ~riment and osmolar clearance only at 60 minute ; of Li´ pulse.
6) Fi om above results, it was discussed that:
( Hydrocortisone would correct impaired Li+ clearance and Li´-induced diuresis found in adrena´.ectomy.
02 Incomplete Li+-induced diuresis found in adrena lectomy would be accounted for by enhanced vasopr ~ssin secretion.
C Hydrocortisone would correct the inappropriate fall in plasma Li+ concentration caused by adrenalectomy.
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KEYWORD
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